PT  - JOURNAL ARTICLE
ED  - Brouhard, Ben H.
AU  - Samuel J. Hassenbusch
AU  - James H. Anderson
AU  - Donald M. Whiting
TI  - Intra-arterial chemotherapy for brain tumors
DP  - 1990 Sep 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 513--520
VI  - 57
IP  - 6
4099  - http://www.ccjm.org/content/57/6/513.short
4100  - http://www.ccjm.org/content/57/6/513.full
SO  - Cleve Clin J Med1990 Sep 01; 57
AB  - Direct comparisons of theoretical modeling with actual drug delivery can lead to improved brain tumor therapy. In this study, normal and brain tumor-bearing rabbits received infusions of BCNU, or carmustine (1,3-bis [2-chlorethyl]-l-nitrosourea), with ethanol or hyperoxygenated perfluorocarbons as B C N U diluent. When ethanol was used as a diluent, right (infused) hemisphere deft (noninfused) hemisphere ratios of BCNU concentrations in both rabbit groups were markedly lower than had been predicted with theoretical pharmacokinetic modeling. When perfluorocarbons were used as a diluent, ratios of BCNU were significantly improved. These laboratory studies were directly translated into a two-phase protocol for human brain tumor patients. This combined research program demonstrates the successful integration of laboratory and clinical programs.