RT Journal Article
SR Electronic
T1 Intra-arterial chemotherapy for brain tumors
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 513
OP 520
VO 57
IS 6
A2 Ben H. Brouhard
A1 Samuel J. Hassenbusch
A1 James H. Anderson
A1 Donald M. Whiting
YR 1990
UL http://www.ccjm.org/content/57/6/513.abstract
AB Direct comparisons of theoretical modeling with actual drug delivery can lead to improved brain tumor therapy. In this study, normal and brain tumor-bearing rabbits received infusions of BCNU, or carmustine (1,3-bis [2-chlorethyl]-l-nitrosourea), with ethanol or hyperoxygenated perfluorocarbons as B C N U diluent. When ethanol was used as a diluent, right (infused) hemisphere deft (noninfused) hemisphere ratios of BCNU concentrations in both rabbit groups were markedly lower than had been predicted with theoretical pharmacokinetic modeling. When perfluorocarbons were used as a diluent, ratios of BCNU were significantly improved. These laboratory studies were directly translated into a two-phase protocol for human brain tumor patients. This combined research program demonstrates the successful integration of laboratory and clinical programs.