RT Journal Article SR Electronic T1 Intra-arterial chemotherapy for brain tumors JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 513 OP 520 VO 57 IS 6 A2 Brouhard, Ben H. A1 Hassenbusch, Samuel J. A1 Anderson, James H. A1 Whiting, Donald M. YR 1990 UL http://www.ccjm.org/content/57/6/513.abstract AB Direct comparisons of theoretical modeling with actual drug delivery can lead to improved brain tumor therapy. In this study, normal and brain tumor-bearing rabbits received infusions of BCNU, or carmustine (1,3-bis [2-chlorethyl]-l-nitrosourea), with ethanol or hyperoxygenated perfluorocarbons as B C N U diluent. When ethanol was used as a diluent, right (infused) hemisphere deft (noninfused) hemisphere ratios of BCNU concentrations in both rabbit groups were markedly lower than had been predicted with theoretical pharmacokinetic modeling. When perfluorocarbons were used as a diluent, ratios of BCNU were significantly improved. These laboratory studies were directly translated into a two-phase protocol for human brain tumor patients. This combined research program demonstrates the successful integration of laboratory and clinical programs.