TY - JOUR T1 - Intra-arterial chemotherapy for brain tumors JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 513 LP - 520 VL - 57 IS - 6 AU - Samuel J. Hassenbusch AU - James H. Anderson AU - Donald M. Whiting A2 - Brouhard, Ben H. Y1 - 1990/09/01 UR - http://www.ccjm.org/content/57/6/513.abstract N2 - Direct comparisons of theoretical modeling with actual drug delivery can lead to improved brain tumor therapy. In this study, normal and brain tumor-bearing rabbits received infusions of BCNU, or carmustine (1,3-bis [2-chlorethyl]-l-nitrosourea), with ethanol or hyperoxygenated perfluorocarbons as B C N U diluent. When ethanol was used as a diluent, right (infused) hemisphere deft (noninfused) hemisphere ratios of BCNU concentrations in both rabbit groups were markedly lower than had been predicted with theoretical pharmacokinetic modeling. When perfluorocarbons were used as a diluent, ratios of BCNU were significantly improved. These laboratory studies were directly translated into a two-phase protocol for human brain tumor patients. This combined research program demonstrates the successful integration of laboratory and clinical programs. ER -