RT Journal Article
SR Electronic
T1 Recombinant t-PA and platelet activity
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 537
OP 541
VO 57
IS 6
A1 Becker, Richard C.
YR 1990
UL http://www.ccjm.org/content/57/6/537.abstract
AB Platelet-rich coronary arterial occlusions are relatively resistant to thrombolysis with recombinant tissue-type plasminogen activator, or rt-PA, while erythrocyte-rich thrombi are lysed at low doses. The combined administration of rt-PA with a platelet antagonist enhances thrombolysis and can prevent reocclusion, which suggests that platelet activation predominates during thrombus formation and after thrombolysis. In addition to direct effects on platelet activity, rt-PA also acts indirectly through generation of plasmin, which degrades fibrin.