TY - JOUR T1 - Ultrastructural and immunomorphologic study of perinuclear filaments in Merkel cell tumors JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 103 LP - 110 VL - 52 IS - 1 AU - James T. McMahon AU - Raymond R. Tubbs AU - Wilma F. Bergfeld AU - Ronald G. Wheeland AU - Philip L. Bailin A2 - Hart, William R. Y1 - 1985/03/20 UR - http://www.ccjm.org/content/52/1/103.abstract N2 - Two cases of cutaneous small-cell tumor in patients without overt lung disease are presented. Histologic and ultrastructural findings support the diagnosis of Merkel cell tumor. Immunohistochemistry and immunoelectron microscopy demonstrate distinctive perinuclear keratin filaments that may be of histologic significance in separating a Merkel cell tumor from other nonendocrine tumors. A possible mechanism for the formation of perinuclear filamentous whorls is discussed. ER -