RT Journal Article
SR Electronic
T1 Ultrastructural and immunomorphologic study of perinuclear filaments in Merkel cell tumors
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 103
OP 110
VO 52
IS 1
A2 Hart, William R.
A1 McMahon, James T.
A1 Tubbs, Raymond R.
A1 Bergfeld, Wilma F.
A1 Wheeland, Ronald G.
A1 Bailin, Philip L.
YR 1985
UL http://www.ccjm.org/content/52/1/103.abstract
AB Two cases of cutaneous small-cell tumor in patients without overt lung disease are presented. Histologic and ultrastructural findings support the diagnosis of Merkel cell tumor. Immunohistochemistry and immunoelectron microscopy demonstrate distinctive perinuclear keratin filaments that may be of histologic significance in separating a Merkel cell tumor from other nonendocrine tumors. A possible mechanism for the formation of perinuclear filamentous whorls is discussed.