PT  - JOURNAL ARTICLE
AU  - Young, Thomas L.
AU  - Achkar, Edgar
AU  - Tuthill, Ralph
AU  - Ferguson, D. Roy
TI  - Chronic active hepatitis induced by nitrofurantoin
DP  - 1985 Jun 20
TA  - Cleveland Clinic Journal of Medicine
PG  - 253--256
VI  - 52
IP  - 2
4099  - http://www.ccjm.org/content/52/2/253.short
4100  - http://www.ccjm.org/content/52/2/253.full
SO  - Cleve Clin J Med1985 Jun 20; 52
AB  - In 2 women who had received nitrofurantoin for two to five years, autoimmune chronic hepatitis developed, leading to sevère hepatic necrosis and, in one case, cirrhosis. Treatment consisted of withdrawal and, in one case, institution of steroids and azathioprine. Both patients demonstrated symptomatic and biochemical improvement despite chronic histological changes. Nitrofurantoin is a cause of "lupoid" chronic active hepatitis which could lead to severe and irreversible histological changes.