RT Journal Article
SR Electronic
T1 Chronic active hepatitis induced by nitrofurantoin
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 253
OP 256
VO 52
IS 2
A1 Young, Thomas L.
A1 Achkar, Edgar
A1 Tuthill, Ralph
A1 Ferguson, D. Roy
YR 1985
UL http://www.ccjm.org/content/52/2/253.abstract
AB In 2 women who had received nitrofurantoin for two to five years, autoimmune chronic hepatitis developed, leading to sevère hepatic necrosis and, in one case, cirrhosis. Treatment consisted of withdrawal and, in one case, institution of steroids and azathioprine. Both patients demonstrated symptomatic and biochemical improvement despite chronic histological changes. Nitrofurantoin is a cause of "lupoid" chronic active hepatitis which could lead to severe and irreversible histological changes.