PT - JOURNAL ARTICLE AU - Rudolph B. Rustin AU - David P. Vogt AU - Ronald M. Bukowski AU - Kirk V. Shepard TI - Hepatic artery infusion chemotherapy for colorectal liver metastases DP - 1990 Nov 01 TA - Cleveland Clinic Journal of Medicine PG - 692--696 VI - 57 IP - 8 4099 - http://www.ccjm.org/content/57/8/692.short 4100 - http://www.ccjm.org/content/57/8/692.full SO - Cleve Clin J Med1990 Nov 01; 57 AB - Twenty-two patients with hepatic colorectal metastases had Infusaid pumps implanted for hepatic artery infusion chemotherapy, or HAIC. Prior to pump placement, 19 of the 22 patients received percutaneous HAIC with 5-fluorouracil and citrovorum factor. Floxuridine, 0.2 mg/kg/d, was administered via the Infusaid pump and was alternated with saline solution every 2 weeks. HAIC responsiveness was defined as a 50% or greater reduction in the sum of all diameters of measured lesions on computerized tomography scans and no evidence of extra-hepatic tumor. Nine patients (41%) had a favorable response to HAIC; four (18%) had a partial response to percutaneous HAIC and five (23%) were considered pump responders. All responders had pretreatment liver replacement of less than 50%. The mean survival after pump placement was 13.6 months for responders and 11.1 months for non-responders. Although there were no operative deaths, the morbidity rate was 36%, and 31% of patients manifested significant chemotherapy toxicity. While toxicity is not insignificant and there is no survival benefit, the Infusaid pump is a reliable drug delivery system for HAIC, and may result in regression of colorectal liver metastases in patients with less than 50% hepatic replacement.