%0 Journal Article %A Jack Khouri %A Christy Samaras %A Jason Valent %A Alex Mejia Garcia %A Beth Faiman %A Saveta Mathur %A Kim Hamilton %A Megan Nakashima %A Matt Kalaycio %T Monoclonal gammopathy of undetermined significance: A primary care guide %D 2019 %R 10.3949/ccjm.86a.17133 %J Cleveland Clinic Journal of Medicine %P 39-46 %V 86 %N 1 %X Monoclonal gammopathy of undetermined significance (MGUS) is commonly diagnosed in outpatients being worked up for an array of clinical concerns. It carries a risk of progression to myeloma and other lymphoproliferative disorders that, albeit low (1% per year), warrants regular follow-up. Patients with MGUS can be risk-stratified on the basis of the amount and type of their monoclonal protein as well as whether they have an abnormal light-chain ratio. Here, we provide a guide to the diagnosis, workup, and management of MGUS. %U https://www.ccjm.org/content/ccjom/86/1/39.full.pdf