PT - JOURNAL ARTICLE AU - Rebecca Flyckt AU - Tommaso Falcone TI - Infertility: A practical framework AID - 10.3949/ccjm.86a.18068 DP - 2019 Jul 01 TA - Cleveland Clinic Journal of Medicine PG - 473--482 VI - 86 IP - 7 4099 - http://www.ccjm.org/content/86/7/473.short 4100 - http://www.ccjm.org/content/86/7/473.full SO - Cleve Clin J Med2019 Jul 01; 86 AB - Fertility concerns are common in men and women of reproductive age, and primary care physicians are often the first line in addressing, assessing, and referring these patients. This article reviews the answers to questions patients often ask, and outlines a practical framework for the evaluation and management of the infertile couple. Up-to-date information is provided on available assisted reproductive technologies for the infertile couple, as well as preserving fertility in the setting of aging-related changes in the female reproductive system.