TABLE 1

Guidelines for performing endotracheal intubation in patients with COVID-19

PreparationIntubation
• Hand hygiene
• Full PPE per guidelines from CDC; use buddy system
• Team member outside room to help (full PPE)
• Prepare medications outside room
• Have ventilator available in room prior to intubation
• Reliable intravenous access
• Optimize patient position for intubation
• Airway assessment
• If difficult airway, have a team capable of performing emergency surgical airway available

Equipment needed in room
• Endotracheal tube (size 7.5 or 8 mm) with stylet
• Video laryngoscope
• LMA size 4
• Intubation bougie
• Magill forceps
• HME/HEPA filter
• Capnograph
• Suction
• Endotracheal tube holder
• 10 cc syringe
• Fluid bag
• Barrier device
• Preoxygenation with 100% non-rebreather mask for 3 to 5 minutes
• Do not initiate noninvasive ventilation
• Rapid sequence intubation; avoid bag mask ventilation
• Attach HME filter immediately after intubation
• Avoid auscultation to confirm endotracheal tube position
• Confirm tube position with inline capnograph
• If difficulty encountered, use supraglottic airway device (LMA)

Intubating medications
Induction agents
 a. Propofol 1 to 2.5 mg/kg
 b. Etomidate 0.2 to 0.3 mg/kg
 c. Ketamine 1 to 2 mg/kg
 d. Methohexital 1 to 2 mg/kg
Neuromuscular blocking agents
 a. Succinylcholine 1.0 to 1.5 mg/kg
 b. Rocuronium 1.2 mg/kg

Initial ventilator settings
• Pressure-regulated volume control with tidal volume
6 to 8 mL/kg of ideal body weight
• Plateau pressure < 30 cm H20
• FiO2 1.0 (FiO2 should be titrated to SPO2 > 92%)
• Respiratory rate 12 breaths per minute

Postintubation
• Doffing per CDC protocol (use buddy system)
• Order chest radiograph
• Consider placing orogastic tube and invasive lines (eg, arterial and central venous pressure lines)
  • CDC = US Centers for Disease Control and Prevention; HEPA = high efficiency particulate air; HME = heat and moisture exchanger; LMA = laryngeal mask airway; PPE = personal protective equipment