TABLE 2

Failure criteria for noninvasive ventilation (NIV) and high-flow nasal cannula (HFNC)

NIV Failure Criteria
• Tidal volume > 9.5 mL/kg/IBW consistently over the first 4 hours
• FiO2 > 60% to maintain target SpO2
HFNC Failure Criteria
• ROX scorea ≥ 4.88 at 2, 6 and 12 hrs is a good predictor of no need for intubation and < 3.85 is high risk for need for intubation
  • a ROX score = (SpO2/FiO2)/RR.