Disease associations of specific antigen targets
| Antigen target | Disease association |
|---|---|
| Double-stranded DNA and Sm | Systemic lupus erythematosus |
| Ro and La | Sjögren syndrome; Ro also associated with subacute cutaneous lupus |
| U1-RNP | Mixed connective tissue disease |
| Jo-1 | Polymyositis (higher risk of interstitial lung disease) |
| ScL-70 | Diffuse cutaneous scleroderma |
| Anticentromere | Limited cutaneous scleroderma |