If D-dimer is < 3,000 FEU or unknown, and:
No renal impairment: enoxaparin 40 mg every 24 hours Creatinine clearance 10–30 mL/hour: enoxaparin 30 mg every 24 hours Creatinine clearance < 10 mL/hour, acute kidney injury, or dialysis: heparin 5,000 units every 12 hours
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If D-dimer is ≥ 3,000 FEU or critically ill patient (independent of D-dimer level), and:
No renal impairment: enoxaparin 40 mg every 12 hours Creatinine clearance 10–30 mL/hour: enoxaparin 40 mg every 24 hours Creatinine clearance < 10 mL/hour, acute kidney injury, or dialysis: heparin 7,500 units every 12 hours
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