Trial | Agent | Composite kidney outcome | Primary or secondary end points | Hazard ratio (95% CI) | Number needed to treat |
---|---|---|---|---|---|
EMPA-REG OUTCOME8 | Empagliflozin | Doubling of the serum creatinine level, initiation of kidney replacement therapy, or death from renal disease | Secondary | 0.54 (0.40–0.75) | 194 |
CANVAS10 | Canagliflozin | Sustained 40% reduction in eGFR, need for kidney replacement therapy, or death from renal causes | Secondary | 0.60 (0.47–0.77) | 286 |
DECLARE-TIMI 5811 | Dapagliflozin | Sustained ≥ 40% reduction in eGFR to < 60 mL/min/1.73 m2, new end-stage kidney disease, or death from renal cause | Secondary | 0.53 (0.43–0.66) | 78 |
EMPEROR-Reduced9 | Empagliflozin | Sustained ≥ 40% reduction in eGFR, chronic dialysis, renal transplant, or sustained eGFR < 10–15 mL/min/1.73 m2 | Secondary | 0.50 (0.32–0.77) | 68 |
CREDENCE12 | Canagliflozin | End-stage kidney disease, doubling of the serum creatinine level, or death from renal or cardiovascular causes | Primary | 0.70 (0.59–0.82) | 22 |
DAPA-CKD13 | Dapagliflozin | Sustained ≥ 50% reduction in eGFR, end-stage kidney disease, or death from renal or cardiovascular cause | Primary | 0.61 (0.51–0.72) | 19 |
EMPA-KIDNEY14 | Empagliflozin | End-stage kidney disease, a sustained reduction in eGFR to < 10 mL/min/1.73 m2, renal death, or a sustained decline of ≥ 40% in eGFR | Primary | Ongoing | Ongoing |
CANVAS = Canagliflozin Cardiovascular Assessment Study; CI = confidence interval; CREDENCE = Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation; DAPA-CKD = Dapagliflozin in Patients With Chronic Kidney Disease; DECLARE-TIMI 58 = Dapagliflozin Effect on Cardiovascular Events; eGFR = estimated glomerular filtration rate; EMPA-KIDNEY = Study of Heart and Kidney Protection With Empagliflozin; EMPA-REG OUTCOME = Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients; EMPEROR-Reduced = Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Reduced Ejection Fraction