Dosing of antifibrinolytic agents

Tranexamic acid1–1.5 g orally every 8–12 hours for duration of bleeding
10-20 mg/kg intravenous (IV) bolus followed by 10 mg/kg IV every 6–8 hours for major bleeding, hemophilic bleeding, or after major trauma
Longer intervals for renal insufficiency
Epsilon-aminocaproic acid3 g orally 3–4 times per day
2 g IV every 6 hours or 1 g IV every hour, depending on the urgency
Desmopressin0.3 μg/kg subcutaneously
0.3 μg/kg IV in 50 mL of normal saline over 15–30 minutes
  • Information from reference 17.