TABLE 2

When to give high vs low dose andexanet alfa infusion

DrugLast doseTime from last dose
< 8 hours or unknown≥ 8 hours
Apixaban≤ 5 mgLow doseaLow dose
> 5 mg or unknownHigh dosebLow dose
Rivaroxaban≤ 10 mgLow doseLow dose
>10 mg or unknownHigh doseLow dose

  • ↵a Low dose: 400 mg intravenous bolus at a target rate of 30 mg/minute, followed by 4 mg/minute for up to 120 minutes.

  • ↵b High dose: 800 mg intravenous bolus at a target rate of 30 mg/minute, followed by 8 mg/minute for up to 120 minutes.