Prophylaxis of venous thromboembolism in elderly hip fracture patients
| Drug | Dosing and route of administration | FDA-approved for VTE prophylaxis? |
|---|---|---|
| Low-molecular-weight heparin | Enoxaparin 40 mg subcutaneously daily | Yes |
| Fondaparinux | 2.5 mg subcutaneously daily | Yes |
| Warfarin | 3–5 mg by mouth daily for goal international normalized ratio 2–3 | Yes |
| Unfractionated heparin | 5,000 U every 8 hours, every 12 hours for patients weighing < 50 kg Use if creatinine clearance rate is < 230 mL/min | Yes |
| Aspirin | Unclear, dosing ranges from 81 mg orally twice a day for creatinine clearance rate < 30 mL/min, to 325 mg orally twice a day | No |
| Apixaban | 2.5 mg orally twice a day | No |
| Dabigatran | 150 mg orally daily | No |
| Rivaroxaban | 10 mg orally daily | No |
FDA = US Food and Drug Administration; VTE = venous thromboembolism
Based on information in reference 37.