Prophylaxis of venous thromboembolism in elderly hip fracture patients

DrugDosing and route of administrationFDA-approved for VTE prophylaxis?
Low-molecular-weight heparinEnoxaparin 40 mg subcutaneously dailyYes
Fondaparinux2.5 mg subcutaneously dailyYes
Warfarin3–5 mg by mouth daily for goal international normalized ratio 2–3Yes
Unfractionated heparin5,000 U every 8 hours, every 12 hours for patients weighing < 50 kg
Use if creatinine clearance rate is < 230 mL/min
AspirinUnclear, dosing ranges from 81 mg orally twice a day for creatinine clearance rate < 30 mL/min, to 325 mg orally twice a dayNo
Apixaban2.5 mg orally twice a dayNo
Dabigatran150 mg orally dailyNo
Rivaroxaban10 mg orally dailyNo
  • FDA = US Food and Drug Administration; VTE = venous thromboembolism

  • Based on information in reference 37.