Quetiapine activity in the central nervous system
| Doses | Low (25-100 mg daily) | Medium (300-600 mg daily) | High (> 800 mg daily) | |
|---|---|---|---|---|
| Receptors | Histamine 1 | Alpha 1/alpha 2 adrenergic | 5-HT1A, 5-HT2A/B, 5-HT2C | D2 |
| Activity | Antihistaminergic | Antiadrenergic | Serotonergic | Antidopaminergic |
| Effect | Sedation | Antidepressant properties | Antipsychotic properties | |