Agent | Potential drug interactions |
---|---|
Nicotine replacement therapies | Adenosine, cimetidine, varenicline |
Varenicline | Alcohol, nicotine, OCT2 inhibitors (eg, histamine-2-receptor blockers, quinolones, tafenoquine, trimethoprim) |
Bupropion | Drugs that lower seizure threshold (eg, alcohol, selective serotonin reuptake inhibitors, tricyclic antidepressants, systemic steroids) |
CYP2D6 substrates (eg, aripiprazole, atomoxetine, brexpiprazole, clozapine, codeine, duloxetine, fesoterodine, galantamine, hydrocodone, iloperidone, metoprolol, metoclopramide, nebivolol, pimozide, primaquine, selective serotonin reuptake inhibitors, tamoxifen, tamsulosin, thioridazine, tramadol, tricyclic antidepressants, valbenazine, vortioxetine) | |
Dopaminergic medications (eg, amantadine, levodopa) | |
CYP2B6 inducers (eg, carbamazepine, efavirenz, nelfinavir, nevirapine, phenobarbital, phenytoin, primidone, rifampin, ritonavir) | |
CYP2B6 inhibitors (eg, clopidogrel, mifepristone; ticlopidine) | |
Digoxin, monoamine oxidase inhibitors | |
Cigarette smoke | CYP1A2 substrates (eg, clozapine, fluvoxamine, olanzapine, tacrine, theophylline) |
OCT2 = organic cation transporter 2
Based on information in references 24, 43, and 49.