TABLE 3

Weight loss in randomized, double-blind, placebo-controlled trials

MedicationPatientsDose% TBWL vs placebo
Liraglutide10Diabetes, body mass index (BMI) ≥ 27 kg/m21.8 mg
3.0 mg
2.7
4.0
Liraglutide11Prediabetes, BMI ≥ 30 or ≥ 27 with hypertension or dyslipidemia3.0 mg5.4
Liraglutide12No diabetes, BMI ≥ 30 or ≥ 27 with hypertension or dyslipidemia, who lost ≥ 5% total body weight with a low-calorie diet3.0 mg6.0
Naltrexone-bupropion13Diabetes, BMI ≥ 2732/360 mg3.2
Naltrexone-bupropion14No diabetes, BMI ≥ 30 or ≥ 27 with hypertension or dyslipidemia16/360 mg
32/360 mg
3.7
4.8
Naltrexone-bupropion15No diabetes, BMI ≥ 30 or ≥ 27 with hypertension or dyslipidemia32/360 mg5.2
Naltrexone-bupropion16No diabetes, BMI ≥ 30 or ≥ 27 with hypertension or dyslipidemia32/360 mg4.2
Orlistat17BMI 30–43120 mg TID3.0
Orlistat18BMI 30–44120 mg TID3.7
Orlistat19Type 2 diabetes, clinically stable on oral sulfonylureas, BMI 28–40120 mg TID1.9
Phentermine-topiramate ER20No diabetes, BMI ≥ 35, blood pressure ≤ 140/90 mm Hg3.75/23 mg
15/92 mg
3.5
9.3
Phentermine-topiramate ER21BMI 27–45 with at least 2 of the following: hypertension, dyslipidemia, diabetes, prediabetes, abdominal obesity7.5/46 mg
15/92 mg
8.0
10.8
Phentermine-topiramate ER22BMI 27–45 with at least 2 of the following: hypertension, dyslipidemia, diabetes, prediabetes, abdominal obesity7.5/46 mg
15/92 mg
7.1
8.5
Phentermine-topiramate ER23BMI 30–457.5/46 mg
15/92 mg
6.8
7.5
Lisdexamfetamine24Adults with binge eating disorder, BMI 25–4530 mg
50 mg
70 mg
3.3
5.2
5.3
Phentermine23BMI 30–457.5 mg
15 mg
3.7
4.4
Topiramate23BMI 30–4546 mg
92 mg
3.4
4.7
Metformin25No diabetes, BMI ≥ 24 (≥ 22 in Asian Americans), elevated fasting glucose or impaired glucose tolerance850 mg BID2.3
Pramlintide26No diabetes, BMI 30–50120 μg TID
360 μg TID
5.6
6.8
Canagliflozin27
Semaglutide10
Semaglutide11
No diabetes, BMI 27–50
No diabetes, BMI ≥ 30, or ≥ 27 with at least 1 obesity-associated comorbidity
Diabetes, BMI ≥ 27
50 mg
100 mg
300 mg
2.4 mg/week
2.4 mg/week
0.9
1.6
1.4
12.4
6.2
  • BID = twice a day; ER = extended release; TID = three times a day; TBWL = total body weight loss