Randomized controlled trials of corticosteroids in septic shock
| Author and year | Number of patients | Major findings |
|---|---|---|
| Annane et al,68 2002 | 300 | Lower mortality rate and shorter duration of shock in corticotropin nonresponders with hydrocortisone + fludrocortisone, but not in all patients |
| Sprung et al,69 2008 | 499 | No difference in mortality rate, but shorter duration of shock and no increased risk of superinfection with hydrocortisone |
| Keh et al,70 2016 | 380 | No benefit of hydrocortisone in preventing septic shock or decreasing mortality in severe sepsis |
| Annane et al,66 2018 | 1,241 | Lower mortality rate and shorter duration of shock and mechanical ventilation with addition of hydrocortisone + fludrocortisone. |
| Venkatesh et al,67 2018 | 3,800 | No reduction in mortality with addition of hydrocortisone, but reduced duration of shock, mechanical ventilation and length of stay in intensive care unit |