Randomized controlled trials of volume replacement in sepsis and septic shock
| Author and year | Number of patients | Major findings |
|---|---|---|
| Finfer et al,43 2004 | 6,997 | No reduction in mortality with albumin compared with saline |
| Perner et al,47 2012 | 804 | Higher risk of death and renal replacement therapy with hydroxyethyl starch compared with Ringer solution |
| Annane et al,45 2013 | 2,587 | No reduction in mortality, need for renal replacement therapy, duration of resuscitation, or length of stay with colloids compared with crystalloids |
| Caironi et al,44 2014 | 1,818 | No reduction in mortality, need for renal replacement therapy, or length of stay with albumin replacement |
| Young et al,41 2015 | 2,278 | No difference in incidence of acute kidney injury, need for renal replacement therapy, or length of stay with balanced solution compared with saline |
| Semler et al,40 2018 | 15,802 | Lower rates of mortality and need for renal replacement therapy with balanced solutions compared with saline |