Treatment with different antiresorptive drug classes led to similar vertebral fracture reduction despite different magnitudes of change in bone density.4,5 |
Early fracture rate improved with risedronate therapy despite no observable bone density changes.6 |
High and low doses of teriparatide led to similar rates of vertebral fracture reduction but different increases in bone density.7 |
Large-dose sodium fluoride to treat osteoporosis led to more fractures despite increased bone density.8 |
A high prevalence of low-impact fractures occurred despite abnormally elevated bone mineral density in 2 patients with autosomal-dominant osteopetrosis.9 |
Patients with diabetes have increased fracture risk despite normal bone density.10,11 |
Patients with hyperparathyroidism exhibit discordance between fracture rates and central and peripheral bone density.12 |
Fracture risk with glucocorticoids is independent of bone mineral density and correlates better with bone microarchitecture measures.13,14 |
More than half of older women with incident hip fracture did not have a diagnosis of osteoporosis up to 5 years previously.15 |