Randomized controlled trials of vasopressors and inotropes in septic shock
| Author and year | Number of patients | Major findings |
|---|---|---|
| Annane et al,62 2007 | 330 | No difference in mortality with epinephrine vs norepinephrine ± dobutamine; higher lactate elevation and lower pH in epinephrine group |
| Russell et al,57 2008 | 780 | No reduction in mortality with addition of vasopressin to norepinephrine Survival benefit in patients with septic shock requiring norepinephrine < 15 μg/min Vasopressin had norepinephrine-sparing effect. |
| De Backer et al,51 2010 | 1,679 | Higher rates of mortality and arrhythmia with dopamine than with norepinephrine |
| Gordon et al,56 2016 | 409 | No improvement in kidney failure-free days, use of renal replacement therapy, or mortality with vasopressin |
| Khanna et al,60 2017 | 344 | Angiotensin II increased blood pressure in refractory vasodilatory shock |