TABLE 4

Randomized controlled trials evaluating early goal-directed care in septic shock

Author and yearNumber of patientsMajor findings
Rivers et al,61 2001  268Significantly lower mortality rate with protocolized care
Peake et al,82 20141,600No reduction in mortality, need for advanced respiratory or renal support, or intensive care unit length of stay with protocolized care
Rowan et al,85 20141,351No reduction in mortality, need for advanced respiratory or renal support, or intensive care unit length of stay with protocolized care
Mouncey et al,83 20151,260No reduction in mortality, need for advanced respiratory, cardiovascular or renal support, or intensive care unit length of stay with protocolized care