Treatment of uncomplicated malaria
| Plasmodium species | Region | Recommended medication |
|---|---|---|
| P falciparum or species not identified | Chloroquine-resistant (all areas except Central America or the Caribbean) or unknown | Atovaquone-proguanil Artemether-lumefantrine Quinine sulfate + doxycyline, clindamycin, or tetracycline Mefloquinea |
| Chloroquine-sensitive (Central America or the Caribbean) | Chloroquine phosphate Hydroxychloroquine | |
| P malariae or P knowlesi | All | Chloroquine phosphate Hydroxychloroquine |
| P vivax or P ovale | Chloroquine-sensitive | Chloroquine phosphate + primaquine phosphate or tafenoquine Hydroxychloroquine + primaquine phosphate or tafenoquine |
| P vivax | Chloroquine-resistant (Papua New Guinea or Indonesia) | Quinine sulfate + doxycyline or tetracycline + primaquine phosphate or tafenoquine Atovaquone-proguanil + primaquine phosphate or tafenoquine Mefloquine + primaquine phosphate or tafenoquine |
| Alternatives for pregnant women | Chloroquine-sensitive | Chloroquine phosphate Hydroxychloroquine |
| Chloroquine-resistant P falciparum and P vivax | Artemether-lumefantrine (2nd or 3rd trimester only) Quinine sulfate + clindamycin (all trimesters) Mefloquine (all trimesters)a |
↵a Do not use in mefloquine-resistant areas (eg, Thailand, Myanmar, Cambodia, Vietnam).