Increasing size |
Size greater than 5 cm (ie, golf-ball size) |
Deeper-lying mass (deep to fascia) |
Firmer than surrounding tissue |
Patient has potential risk factors (previous radiotherapy, chronic lymphedema, inherited syndrome such as Gardner syndrome, Li-Fraumeni syndrome, and von Recklinghausen disease) |
Local symptoms and signs of infiltration |
With or without pain (large painless lumps should raise concern) |
The greater the number of clinical features, the greater the risk of malignancy. |