Diagnostic criteria for anaphylaxis

Anaphylaxis is highly likely when any 1 of the following 3 criteria is met:
1Sudden onset of symptoms (minutes to several hours) with involvement of skin and/or mucosa (eg, generalized hives, itching or flushing, swollen lips/tongue/uvula), AND at least one of the following:
Respiratory symptoms or signs (eg, shortness of breath, wheezing, cough, hypoxemia)
Hypotension or other symptoms of target-organ dysfunction (eg, collapse, incontinence)
2Sudden onset of 2 or more of the following after exposure to a likely allergen or other trigger for that patient (minutes to several hours):
Skin or mucosal membrane symptoms
Respiratory symptoms
Hypotension or other symptoms of target-organ dysfunction
Gastrointestinal symptoms such as abdominal pain or vomiting
3Hypotension occurring acutely (minutes to several hours) after exposure to a known or established allergen for that patient. Hypotension is defined as the following:
Adults: Systolic blood pressure < 90 mm Hg, or a decrease > 30% from patient’s baseline
Infants and children: Low systolic blood pressure (age-specific) or a decrease > 30% in systolic pressure
  • Based on information from reference 1.