Published phase 2 and 3 trials of roxadustat
| Trial | No. | Patients | Effect on hemoglobin |
|---|---|---|---|
| Besarab et a44 | 104 | Not on dialysis | Better than placebo |
| Chen et al45 | 154 | Not on dialysis or ESAs | Better than placebo |
| ANDES46 | 922 | Not on dialysis or ESAs | Better than placebo |
| OLYMPUS47 | 2,781 | Not on dialysis | Better than placebo |
| ALPS48 | 594 | Not on dialysis or ESAs | Better than placebo |
| Besarab et al51 | 60 | On dialysis, or ESAs | Better than baseline |
| Chen et al52 | 305 | On dialysis and ESAs | As good as epoetin alfa |
| HIMALAYAS54 | 1,043 | New to dialysis | As good as epoetin alfa |
| Akizawa et al66 | 303 | On dialysis | As good as darbepoetin alfa |
| Akizawa et al67 | 56 | On dialysis | Better than baseline |
| Akizawa et al68 | 239 | On dialysis | Better than baseline in those not on ESAs |
| Akizawa et al69 | 99 | Not on dialysis or ESAs | Better than baseline |
| Provenzano et al70 | 145 | Not on dialysis | Better than baseline |
| Provenzano et al71 | 90 | On dialysis | As good as epoetin alfa |
ESA = erythropoiesis-stimulating agent