Guidelines to evaluate for hereditary breast cancer

  • Age 50 or younger

  • Ovarian cancer (at any age)

  • Triple-negative breast cancer (at any age)

  • Male breast cancer (at any age)

  • Multiple primary breast cancers

  • Pancreatic cancer

  • Metastatic prostate cancer

  • Three or more diagnoses of breast cancer in the patient or a close blood relative

  • Two or more close (first-degree) relatives with breast or prostate cancer at any age

  • To aid in treatment decisions using poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in patients with metastatic or very-high-risk breast cancer

  • Lobular breast cancer with a personal or family history of diffuse gastric cancer

  • Ashkenazi Jewish ancestry

  • Finding of a mutation in somatic tumor testing

  • A patient without a cancer diagnosis but with a first-, second-, or third-degree relative meeting the above criteria: Exceptions: 1) If patient is eligible for PARP inhibitors; 2) If patient meets testing criteria based only on pancreatic cancer or metastatic prostate cancer, the affected relative must be a first-degree relative

  • Based on information in references 5, 7, and 8.