Age 50 or younger

Ovarian cancer (at any age)

Triple-negative breast cancer (at any age)

Male breast cancer (at any age)

Multiple primary breast cancers

Pancreatic cancer

Metastatic prostate cancer

Three or more diagnoses of breast cancer in the patient or a close blood relative

Two or more close (first-degree) relatives with breast or prostate cancer at any age

To aid in treatment decisions using poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors in patients with metastatic or very-high-risk breast cancer

Lobular breast cancer with a personal or family history of diffuse gastric cancer

Ashkenazi Jewish ancestry

Finding of a mutation in somatic tumor testing

A patient without a cancer diagnosis but with a first-, second-, or third-degree relative meeting the above criteria: Exceptions: 1) If patient is eligible for PARP inhibitors; 2) If patient meets testing criteria based only on pancreatic cancer or metastatic prostate cancer, the affected relative must be a first-degree relative