NAFLD spectrum and classification
| NAFL | Early NASH | Fibrotic NASH | Advanced fibrosis | Cirrhosis | |
|---|---|---|---|---|---|
| Fibrosis stage | No fibrosis | F0–F1 (no or mild fibrosis) | ≥ F2 (significant fibrosis) | ≥ F3 (advanced fibrosis) | F4 |
| Histologic features | ≥ 5% steatosis | ≥ 5% steatosis and inflammation with hepatocyte injury (ballooning) | ≥ 5% steatosis and inflammation with hepatocyte injury | ≥ 5% steatosis and inflammation with hepatocyte injury | Bridging fibrosis |
| Weight loss needed for improvement, % of total | ≥ 5% | ≥ 7% | ≥ 10% | ≥ 10% | Not applicablea |
↵a Some cases of reversal of F4 cirrhosis were observed with significant weight loss, such as with bariatric surgery.10
NAFL = nonalcoholic fatty liver; NAFLD = nonalcoholic fatty liver disease; NASH = nonalcoholic steatohepatitis
Data from references 7–10.