TABLE 1

Ranking of therapies for acetylcholine receptor antibody-positive generalized myasthenia gravis

First-line	Pyridostigmine, prednisone, thymectomy^a
Second-line	Azathioprine, mycophenolate mofetil, intravenous immunoglobulin
Third-line	Methotrexate, tacrolimus,^b eculizumab,^c ravulizumab,^c efgartigimod,^c plasmapheresis
Fourth-line	Rituximab, cyclosporine^b
Fifth-line	Cyclophosphamide

↵a For certain patients with acetylcholine receptor antibody-positive generalized myasthenia gravis without thymoma (see reference 5).
↵b May be considered as an early treatment option, depending on clinical context.
↵c Newer agents with emerging data; may be considered as early treatment option for refractory acetylcholine receptor antibody-positive generalized myasthenia gravis, but cost may be prohibitive.
Based on information in references 5 and 6.