Indications for long-term use of proton pump inhibitors
| Definitive (> 8 weeks) | Conditional |
|---|---|
| Barrett esophagus (unrelated to GERD symptoms or esophagitis) | PPI-responsive, endoscopy-negative reflux disease with recurrence on PPI cessation |
| Erosive esophagitis Los Angeles classification grade C/D | PPI-responsive functional dyspepsia with recurrence on PPI cessation |
| Esophageal stricture due to GERD | PPI-responsive upper-airway symptoms with recurrence on PPI cessation |
| NSAID/antiplatelet users with increased risk of ulcers and bleeding | Refractory steatorrhea in chronic pancreatic insufficiency with enzyme replacement |
| Eosinophilic esophagitis | Secondary prevention of peptic ulcers without concomitant antiplatelet drugs |
| Pathological hypersecretory conditions (Zollinger-Ellison syndrome) | |
| Prevention of progression of idiopathic pulmonary fibrosis |
GERD = gastroesophageal reflux disease; NSAID = nonsteroidal anti-inflammatory drug; PPI = proton pump inhibitors
Based on information in references 21 and 22.