TABLE 1

Common Terminology Criteria for Adverse Events (CTCAE)

Grade 1Grade 2Grade 3Grade 4Grade 5
Asymptomatic or mild symptoms or change in affected chronic condition from baseline (eg, diabetes mellitus)Moderate symptoms; limiting age-appropriate instrumental activities of daily livingSevere or medically significant but not immediately life threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care activities of daily livingLife-threatening consequences; urgent intervention indicatedDeath

  • Adapted from reference 18.