Studies of midodrine in the treatment of septic shock
| Authors | Study design | Patient population | Outcomes |
|---|---|---|---|
| Lal et al9 | Pilot, placebo-controlled, double-blind, randomized trial | Adult medical ICU patients hospitalized with sepsis; mean arterial pressure < 70 mm Hg despite sepsis treatment | Decreased duration of IVPs (P = .19) Decreased total IVP requirement (P = .59) Shorter ICU length of stay (P = .36) Similar hospital length of stay (P = .41) |
| Whitson et al7 | Single-center retrospective cohort study | Patients hospitalized with septic shock requiring at least 24 hours of IVPs who demonstrated a period of clinical stability | Decreased IVP duration (P < .001) Decreased ICU length of stay (P = .017) Reduction in total IVP days and ICU patient days over year of study |
| Adly et al10 | Single-center retrospective control study | Resuscitated patients with septic shock who demonstrated clinical stability on low-dose IVP for at least 24 hours | Reduced IVP (norepinephrine) duration (P = .001) Shorter IVP weaning period in septic shock recovery phase (P < .001) Decreased mortality (43.3% vs 73.3%, P = .018) |
| Santer et al11 | Randomized, double-blind, placebo-controlled trial | Hypotensive adult patients on single-agent IVP unable to be weaned from IVPs for at least 24 hours | No difference in time to IVP discontinuation (23.5 vs 22.5, P = .62) No difference in ICU length of stay (6 days vs 6 days, P = .46) No difference in time to ICU discharge readiness (5 days vs 5 days, P = .64) No difference in ICU readmission rate (1.5% vs 4.5%, P = .62) Increased rates of bradycardia (7.6% vs 0%) |
ICU = intensive care unit; IVP = intravenous vasopressor