Diagnostic tests for evaluation of the etiology of liver cirrhosis
| Diagnostic test | Disease process |
|---|---|
| Hepatitis B surface antigen, immunoglobulin M anti-hepatitis B core antigen | Acute hepatitis B |
| Hepatitis B surface antigen, positive viremia on highly sensitive hepatitis B virus DNA assay | Chronic hepatitis B |
| Anti-hepatitis C virus, hepatitis C virus RNA (confirmatory) | Hepatitis C |
| Antismooth muscle antibody, antinuclear antibody | Autoimmune hepatitis |
| Antiliver kidney microsomal antibody, antisoluble liver antigen antibody (both less common) | Autoimmune hepatitis |
| Iron level, serum ferritin, transferrin saturation | Hemochromatosis |
| Ceruloplasmin | Wilson disease |
| Alpha-1 antitrypsin phenotype | Alpha-1 antitrypsin deficiency |
| Lipid panel, hemoglobin A1c, hepatic ultrasonography | Nonalcoholic fatty liver disease, nonalcoholic steatohepatitis |
| Aspartate aminotransferase > alanine aminotransferase, elevated gamma-glutamyl transferase, elevated mean corpuscular volume | Alcoholic liver disease |
| Antimitochondrial antibody | Primary biliary cholangitis |
Based on information in references 4 and 6.