Laboratory values for a 35-year-old woman who underwent simultaneous pancreas and kidney transplant and developed chronic myeloid leukemia
| Laboratory parameters (reference range) | Pretransplant | 1 week after transplant | Thrombocytopenia admission (about 6.5 years after transplant | Bicytopenic cycle (2 weeks after the thrombocytopenia admission) |
|---|---|---|---|---|
| White blood cell count (4–10 × 109/L) | 20 | 80 | 6 | 7 |
| Hemoglobin (12–16 g/dL) | 10.6 | 9.5 | 11 | 7.8 |
| Platelet count (150–400 × 109/L) | 281 | 440 | 6 | 20 |
| Reticulocyte count (0.5%–1.5%) | NA | NA | 2.1% | 16.3% |
| Neutrophils (1.5–8 × 109/L) | 15 | 29 | 4.4 | 5.3 |
| Lymphocytes (1–5 × 109/L) | 3.5 | 3 | 1.3 | 1.5 |
| Eosinophils (0–0.5 × 109/L) | 0.4 | 0.8 | 0.2 | 0.2 |
| Basophils (0–0.2 × 109/L) | 0.2 | 0.8 | 0.1 | 0.1 |
| Metamyelocytes (0%–1%) | 2% | 11% | NA | NA |
| Myelocytes (0%) | 2% | 1% | NA | NA |
| Promyelocytes (0%) | 2% | NA | NA | NA |
| Peripheral blood smear | NA | Normocytic hypochromic anemia with anisopoikilocytosis, slight polychromasia, a few burr cells, leukocytosis with reactive polymorphonuclear leukocytes and left shift No blasts were seen | Normochromic normocytic anemia with slight polychromasia No increase in schistocytes Marked thrombocytopenia with a few large forms | Normocytic anemia with increased polychromasia, increased microspherocytes No significant schistocytes or blasts Platelets showed normal morphology without clumping |
| Prothrombin time (10–13 seconds) | 13 | 17.3 | 13 | 12.3 |
| International normalized ratio (0.8–1.1) | 1.05 | 1.3 | 1 | 0.9 |
| Partial thromboplastin time (25–35 seconds) | 34 | 45 | 27 | 23 |
| Fibrinogen (200–400 mg/dL) | NA | NA | 367 | NA |
NA = not available