Recommendations for adjunctive corticosteroids in patients with Pneumocystis pneumonia

Patient populationRecommendation
HIV-positive WITH baseline hypoxemiaStrong recommendation that adjunctive corticosteroids improve outcomes with Pneumocystis jirovecii pneumonia treatment
HIV-positive WITHOUT baseline hypoxemiaSteroids should be considered if respiratory status worsens after Pneumocystis jirovecii pneumonia treatment is started
HIV-negative WITH hypoxemia or respiratory failureSteroids should be considered—evidence is unclear
HIV-negative WITH mild to moderate respiratory diseaseSteroids should not be given routinely and may result in worse outcomes
  • HIV = human immunodeficiency virus

  • Based on information in references 513.