Risk stratification of HSCT recipients for progression from upper to lower RTI: MD Anderson Cancer Center Immunodeficiency Scoring Index
| Risk factor at RSV diagnosis | Hazard ratio for progression | Scorea |
|---|---|---|
| Absolute neutrophil count < 500/µL | 4.1 (1.4–11.6) | 3 |
| Absolute lymphocyte count < 200/µL | 2.6 (1.0–6.4) | 3 |
| Age > 40 years | 2.5 (1.1–5.6) | 2 |
| Myeloablative conditioning | 1.2 (0.6–2.3) | 1 |
| Graft-versus-host disease | 1.0 (0.5–2.2) | 1 |
| Corticosteroids within 30 days (> 20 mg prednisone) | 0.89 (0.4–1.8) | 1 |
| Allogeneic HSCT within 30 days (or pre-engraftment) | 0.68 (0.2–2.3) | 1 |
↵aMaximum score = 12: Low risk: 0–2, moderate risk 3–6, high risk 7–12
HSCT = hematopoietic stem cell transplant; RSV = respiratory syncytial virus; RTI = respiratory tract infection
Reprinted from Blood, 123(21), Shah DP, Ghantoji SS, Ariza-Heredia EJ, et al, Immunodeficiency scoring index to predict poor outcomes in hematopoietic cell transplant recipients with RSV infections, 3263–3268, 2014, with permission from Elsevier.