Common Terminology Criteria for Adverse Events grading of diarrhea or colitis5
| Severity grade | Diarrhea | Colitis |
|---|---|---|
| Increase in frequency of bowel movements or loose or watery bowel movements | Inflammation of the colon | |
| Grade 1 | Increase in bowel movements of < 4 stools per day compared with baseline Slight increase in ostomy output | Asymptomatic Only clinical or diagnostic observations No need for intervention |
| Grade 2 | Increase in bowel movements ranging from 4 to 6 stools per day compared with baseline Moderate increase in ostomy output compared with baseline | Abdominal pain Presence of mucus or blood in stool |
| Grade 3 | Increase of ≥ 7 stools per day compared with baseline Severe increase in ostomy output compared with baseline Hospitalization needed | Severe abdominal pain Peritoneal signs |
| Grade 4 | Potential for life-threatening consequences Immediate intervention needed | Potential for life-threatening consequences Immediate intervention needed |
| Grade 5 | Death | Death |