TABLE 3

Alpha-blockers for benign prostatic hyperplasia

DrugTitration required?aDose range (mg)Difference in peak urinary flowb (mL/sec)Difference in IPSSb
Terazosin28,29Yes2–10+0.6 to +1.9−1.0 to −4.0
Doxazosin30,31Yes1–8+1.4 to +3.5−2.1 to −4.7
Alfuzosin32,33Noc10+0.9 to +1.8−1.0 to −2.0
Tamsulosin34,35No0.4–0.8+0.6 to +2.6−1.3 to −3.2
Silodosin36No4–8+0.8 to +1.4−2.3 to −3.0

  • ↵a Titrated to effect and tolerability.

  • ↵b Compared with placebo.

  • ↵c For extended-release formulation.

  • IPSS = International Prostate Symptom Score8