Absolute increase in incidence of the most common adverse effects of alpha-blockers compared with placebo
| Adverse effect | Terazosin28,29 | Doxazosin30 | Alfuzosin38 | Tamsulosin34,35 | Silodosin39 |
|---|---|---|---|---|---|
| Dizziness | 5.9% | 15%–20% | 2% | 5% | 0.6–2.1% |
| Fatigue | 4.6% | 8%–10% | — | 2–3% | — |
| Peripheral edema | 3.1% | — | — | — | — |
| Orthostatic hypotension | 1.4% | 8% | 0.7% | — | 1.1% |
| Ejaculatory dysfunction | 1.2% | — | — | 6%–11% | 22%–27% |