Agents for treating chronic constipation
| Bulk-forming laxatives Insoluble fiber (bran) Soluble fiber (psyllium, methylcellulose, calcium polycarbophil) |
| Osmotic laxatives Polyethylene glycol, lactulose, sorbitol, magnesium hydroxide, magnesium citrate, sodium phosphate enemas |
| Stool softeners Docusate |
| Stimulant laxatives Bisacodyl, anthraquinones, glycerin suppository |
| Intestinal secretagogues Linaclotide, lubiprostone |
| Opioid receptor antagonists Methylnaltrexone, neloxegol |
| AGENTS IN DEVELOPMENT |
| Selective serotonin (5-HT4) agonists Naronapride, prucalopride, velusetrag |
| Ileal bile acid transporter inhibitors Elboxibat |
| Intestinal secretagogues Plecanatide |
| NHE3 sodium transporter inhibitors Tenapanor |