Orlistat (Xenical) | Inhibits pancreatic and gastric lipase | Decreases fat absorption | 120 mg 3 times a day with each main meal containing fat |
Phentermine (Adipex-P, Lomaira) | Augments central norepinephrine release | Decreases appetite | 8 mg to 37.5 mg once daily |
Phentermine and topiramate-extended release (Qsymia) | Augments central norepinephrine and gamma-amino butyric acid release | Decreases appetite | Phentermine 3.75 mg/topiramate 23 mg once daily (initial); phentermine 7.5 mg/ topiramate 46 mg once daily (maintenance) |
Bupropion and naltrexone sustained release (Contrave) | Inhibits dopamine and norepinephrine reuptake; blocks opioid receptor | Decreases appetite | 1 tablet (bupropion 90 mg/naltrexone 8 mg) once daily in morning (intial); 2 tablets (bupropion 180 mg/naltrexone 16 mg) twice daily (usual); maximum daily dose: bupropion 360 mg/naltrexone 32 mg |
Diethylpropion (Tenuate, Tenuate Dospan) | Augments central norepinephrine release | Decreases appetite | 25 mg 3 times a day (immediate release); 75 mg once daily, midmorning (controlled release) |
Lorcaserin (Belviq) | Activates serotonin 5-HT receptor 2C | Decreases appetite | 10 mg twice a day (immediate release) |
Liraglutide (Saxenda) receptor | Activates glucagon-like peptide 1 | Decreases appetite | 3 mg subcutaneously once a day |