Diagnostic tests in endemic mycosis
| Histoplasmosis | Coccidioidomycosis | Blastomycosis | |
|---|---|---|---|
| Culture | Positive in 75% | High yield | High yield |
| Urine antigen detection | 75%–90% sensitivity Cross-reactivity with blastomycosis, paracoccidioidomycosis | Sensitivity and specificity not known | 93% sensitivity 95.6% cross-reactivity with histoplasmosis |
| Serologic testing | High sensitivity Cross-reactivity with blastomycosis and coccidioidomycosis | High sensitivity and specificity | Not useful Poor sensitivity Significant cross-reactivity with histoplasmosis |
| Nucleic acid testing | Uncertain value | Under development | 86% sensitivity 99% specificity |