Reducing the risk of hyperkalemia when using renin-angiotensin-aldosterone system blockers

Assess renal function to define overall risk of hyperkalemia
Discontinue medications that can impair renal potassium excretion, including herbal preparations and over-the-counter nonsteroidal anti-inflammatory drugs
Reduce potassium in diet, avoid salt substitutes containing potassium
Ensure effective diuretic therapy (loop diuretics should be used if the estimated glomerular filtration rate is < 30 mLmin/1.73 m2)
Correct metabolic acidosis when present
Start with low doses of renin-angiotensin-aldosterone system blockers and monitor closely