Neuronal antibodies associated with brainstem and cerebellar encephalitis
| Syndrome | Antigen location | Antibody | Tumor association | Prognosis |
|---|---|---|---|---|
| Brainstem | Intracellular | Anti-Hu (ANNA1) | Small-cell lung cancer | Poor |
| Anti-Ri (ANNA2) | Breast, lung | Poor | ||
| Anti-Ma2 | Testicular germ cell tumor | Good | ||
| Cell surface | Anti-NMDA (second stage disease) | Ovarian teratoma | Very good | |
| Anti-GQ1b | None | Very good | ||
| Anti-NMO (antiaquaporin 4) | None | Good | ||
| Cerebellar | Intracellular | Anti-Yo | Ovarian, breast | Poor |
| Anti-Ri | Breast, lung | Good | ||
| Anti-Tr | Hodgkin lymphoma | Fair | ||
| Anti-GAD | None | Good | ||
| Cell surface | Anti-VGCC | Small-cell lung cancer | Fair | |
| Anti-mGluR1 | Hodgkin lymphoma in remission | Good (three cases re- ported, two improved) |
ANNA = antineuronal nuclear antibody; GAD = glutamic acid decarboxylase; GQ1b = ganglioside GQ1b; mGLuR1 = metabotropic glutamate receptor type 1; NMDA = N-methyl-d-aspartate; NMO = neuromyelitis optica; VGCC = voltage-gated calcium channel